Platelet Count Of Children With Dengue Fever Biology Essay

Platelet Count Of Children With Dengue Fever Biology Essay INTRODUCTION Dengue is a mosquito-borne infection that in recent decades has become a major international public health concern. Dengue is found in tropical and sub-tropical regions around the world, predominantly in urban and semi-urban areas. Dengue haemorrhagic fever (DHF), a potentially lethal complication, was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Today DHF affects most Asian countries and has become a leading cause of hospitalization and death among children in the region. There are four distinct, but closely related, viruses that cause dengue. Recovery from infection by one provides lifelong immunity against that virus but confers only partial and transient protection against subsequent infection by the other three viruses. There is good evidence that sequential infection increases the risk of developing DHF. The incidence of dengue has grown dramatically around the world in recent decades. Some 2.5 billion people two fifths of the worlds population are now at risk from dengue. WHO currently estimates there may be 50 million dengue infections worldwide every year. The disease is now endemic in more than 100 countries in Africa, the Americas, the Eastern Mediterranean, South-east Asia and the Western Pacific. South-east Asia and the Western Pacific are the most seriously affected. Before 1970 only nine countries had experienced DHF epidemics, a number that had increased more than four-fold by 1995. Not only is the number of cases increasing as the disease is spreading to new areas, but explosive outbreaks are occurring. According to government figures 15,061 cases of the disease in the Philippines were reported in the first six months of the year. The increase in the number of dengue cases may be attributed to the constantly changing climate brought by global warming as well as congestion in urban areas. The biggest increase in the country was seen in Metro Manila, where there was an almost 200 percent increase. According to the Department of Health, Southern Mindanao, there is an expected increase in dengue cases in the region because of the onset of the rainy season. About six-percent increase in dengue cases was recorded during the first quarter of the year compared to the same period last year. Davao City still has the highest dengue incidence, with 371 cases recorded in the first quarter. During the same period last year, there were 352 cases recorded in the city. The durian is the fruit of several tree species belonging to the genus Durio and the Malvaceae family. Widely known and revered in Southeast Asia as the king of fruits, the durian is distinctive for its large size, unique odour, and formidable thorn-covered husk. The fruit can grow as large as 30  centimetres (12  in) long and 15  centimetres (6  in) in diameter, and it typically weighs one to three  kilograms (2 to 7  lb). Its shape ranges from oblong to round, the colour of its husk green to brown, and its flesh pale yellow to red, depending on the species. There are 30 recognised Durio species, at least nine of which produce edible fruit. Durio zibethinus is the only species available in the international market; other species are sold in their local region. Studies have shown different uses of durian such as: A.Lipid Lowering Effect: Lipid entrapment property of polysaccharide gel (PG) extracted from fruit-hulls of durian (Durio zibethinus Murr. Cv. Mon-Thong). Results suggest that PG from fruit-hulls of durian may be a potential dietary fiber/ medicinal supplement for a blood lipid / cholesterol lowering effect. B.Hyperthermic Effect / Paracetamol Interaction: Believed to have body-warming properties with concerns on consumption with paracetamol. Rat study showed no significant body temperature elevation. Rats receiving a durian-paracetamol combination showed a significant drop in body temperature. No mechanism for toxicity was identified. C.Antibacterial / Wound Healing Effect: (1) Polysaccharide gel extracted from fruit-hulls of durian seems to have a beneficial effect on wound healing in a pig study.(2) Bactericidal effect of polysaccharide gel was clearly demonstrated against S. aureus and E. coli. Study showed accelerated wound he aling. D.Phenolic Content / Antioxidant Effect: Study showed the durian cultivars high bioactivity and total polyphenols were the main contributors to the overall antioxidant capacity and provides a source of nutritional supplement. Today, Dengue Fever and Dengue Hemorrhagic Fever affect most Asian countries and has become a leading cause of hospitalization in children (about 500,00 cases each year) and death. Until now, there is no specific treatment on dengue fever. Due to this, a significant number of families of patients use different alternative medicines which do not have evidence for cure in the hope of increasing the platelet count of the patient. One of these is the use of D. zibethinus Murr, but its efficacy is still unkown thus the purpose of the study. DEFINITION OF TERMS Dengue Fever a benign syndrome caused by several arthropod-borne viruses, is characterized by biphasic fever, myalgia or arthralgia, rash, leukopenia, and lymphadenopathy Dengue Hemorrhagic Fever a severe, often fatal, febrile disease caused by dengue viruses. It is characterized by capillary permeability, abnormalities of hemostasis, and, in severe cases, a protein-losing shock syndrome (dengue shock syndrome) Dengue Hemorrhagic Fever Grade I presence of fever, non-specific constitutional symptoms, such as anorexia, vomiting, abdominal pain; and positive tourniquet test Dengue Hemorrhagic Fever Grade II symptoms and signs of Grade I plus spontaneous bleeding: mucocutaneous, gastrointestinal Dengue Hemorrhagic Fever Grade III symptoms and signs of Grade II with more severe bleeding plus evidences of circulatory failure: violaceous, cold, clammy skin, restlessness, weak to compressible pulses, narrowing of pulse pressure to 20mmHg or less, or hypotension Dengue Hemorrhagic Fever Grade IV or Dengue Shock Syndrome symptoms and signs of Grade III but shock is usually refractory or irreversible and associated with massive bleeding OBJECTIVES General Objective: This study aims to determine the effect of Durio zibethinus Murr (durian) on the platelet count of pediatric patients with Dengue Fever and Dengue Hemorrhagic Fever Grades I and II. Specific Objectives: To identify the specific component of durian that is capable of increasing the platelet count of dengue patients. To determine the mechanism of action of the active component of durian. To identify significant relationship between the increase of platelet count and intake of durian. METHODOLOGY Study Design Randomized controlled, double-blinded study Study Setting Private Tertiary Hospital Study Subjects Inclusion Criteria Children ages 6 months old to 18 years old diagnosed with dengue fever and dengue hemorrhagic fever grades I and II. Parents/guardians of the subjects who signed the informed consent. Exclusion Criteria Children ages 6 months old to 18 years old diagnosed with dengue hemorrhagic fever III and dengue shock syndrome. Dengue patients who had undergone blood transfusion. Dengue patients who do not eat durian or unable to tolerate the smell of durian. Respondents who developed untoward gastrointestinal side effects during the course of the study, such as nausea, vomiting, diarrhea and dyspepsia. Parents/guardians who did not sign the informed consent. Description of Interventions Patients included in the study will be started with intravenous fluids using Isotonic solutions (D5 LR, D5 NSS/D5 0.9% NaCl) at 3 5 cc/kgBW/hr. Patients were then randomly selected to receive durian decoction (experimental group) and evaporated milk (control group). Decoction will be given three times a day from day of diagnosis to day2 afebrile. Outcome measures Patients data were collected and recorded. Serial platelet monitoring was done every 6 hours, others were every 8 hours and some on a once a day basis during their hospital stay. Patients are also monitored for possible side effects. Data Collection An informed consent has been signed by parents or guardians of the subjects who were included in the study. Socio demographic data were noted (e.g. age and sex). Clinical data as well as the initial laboratory results were noted. Individuals are randomly selected into two groups, one with the Durian decoction, and the other with evaporated milk. Patients diagnosed with Dengue fever, Dengue Hemorrhagic Fever Grades I and II will be selected and observed for the duration of hospital stay. The initial and succeeding platelet count were noted during the introduction of the decoction. Once a day platelet monitoring of all subjects is enough to collect data, provided that it is all taken at the same time. The side effects related to the intake of decoction were all be noted. Preparation of Decoction: Scrapings of durian fruit will be obtained thus removing the fruits seed. __gram of scrapings will be obtained, diluted with __ml of water. __ml of sugar is added to taste. All ingredients is placed in a blender and mixed well to obtain a syrup solution. Administration of the decoction: The decoction will be given to patients with platelet count Dosage: 3mg/kg/day

P Emergency Bail Out

â€Å"We in America today are nearer to the final triumph over poverty than ever before in the history of any land† was Herbert Hoover’s message to voters in the US Presidential race of 1928. However, once elected into office, within months, he came to terms with his own short sightedness as the world plunged into a downward economic spiral, unparallel in history . . . at least until now.The sub prime mortgage crisis and the ensuing credit crunch is by all means a haunting reminder of Black Tuesday, when on October 29, 1929, the NYSE crashed as a result of panic selling and led to the Great Depression.Without dwelling much on history, it can be concluded that the NYSE crash of 1929 and the Housing market crash of 2007 are both characterized by speculation and greed, a fundamental failure of pristine capitalism. Secondly, both crashes have followed an era of loose monetary policy and lax credit regulations for which hot shot individuals at the Central Banks and the comme rcial banks themselves share the blame. To add on to this, we have the menace created by the alluring yet highly risky business of derivatives.With nothing much to defend, the question arises, are we headed towards a depression as in 1929 or is the situation still under control? The likely scenario that we face is a gloomy one. The level of debt that individuals hold is high. The housing crash has wiped out a large portion of the banks credit portfolios. Other advances are also suffering as falling income levels, losses on a highly volatile stock market and rising unemployment are triggering people to default.This is making depositors uneasy as they are shifting money between Banks causing liquidity issues for them. Some Banks have closed down, unable to honor commitments. Others are set to follow. Low liquidity and capital losses means that these financial institutions are refraining from new lending despite the availability of cheap credit. Lack of financial facilitation means tha t businesses are suffering a lack of confidence and the economy is slowing down, marred with deflation, unemployment, high debt levels and low production. The Secretary of the US Treasury, Mr.Hank Paulson’s Emergency Bail out Plan, is set out to counter these problems and save America and the world from recession. The original idea was that the purpose of the plan would be to purchase bad mortgage related assets, reduce uncertainty regarding the worth of the remaining assets, and restore confidence in the credit markets. The treasury was given sweeping powers with 250 billion dollars of immediate funding. If need arose, an additional 100 billion dollars would be available on the discretion of the President and another 350 billion dollars following a congressional resolution.Over time, the plan has come to embody a whole list of objectives including provisions on how to prevent foreclosures, deposit insurance, restrictions on executive pay and equity interests in financial ins titutions. The plan has met a mixed reaction. While there is a strong argument that the plan could be inflationary (Hudson, 2008), some argue that it would tend to be the opposite (UBS, 2008). There is also argument that this plan is aiming to fix a bruised and battered system and that we need a new and revitalized system for credit screening. Detractors also point to the fact that the plan keeps on changing.It seems, from the looks of it, that the treasury is determined to stop the bloodshed with its 700 billion dollars but lacks any coherent strategy to do so. Whatever the case, lets build on basic macroeconomics to see how the plan will affect the American and the world economy and then make an informed conclusion on what the US Treasury should instead aim at. To take a short trip back down history lane, when the 1929 depression struck, John Maynard Keynes argued that Government intervention through a budget deficit would alleviate these conditions.Initially the private sector is unwilling to invest. However, as government spending increases, it raises the private sector’s interest. Gradually, confidence returns. Monetarists held an opposing view. While Keynes argued that higher incomes would lead the poor strata of society to consume more, monetarists held that this additional income would go back to paying off debts and accumulated obligations and not add to the value of the multiplier. (Lipsey & Harbuy, 1992) The US Treasury and the Federal Reserve it seems are following a middle line here.While the Federal Reserve is cutting interest rates to stimulate business activity, capital infusions by the US Treasury is intended to help banks lend more freely. Thus, we are witnessing a mixture of Keynesian and Monetarist school of thought. Although there is little argument to the fact that this plan is inflationary in nature, the problem that it fails to address is that the US Treasury, despite making equity infusions in banks, buying troubled assets, lowe ring interest rates and taking steps to reduce uncertainty cannot force banks to lend.While some point to the inflationary nature of the program and its evolving nature, it seems that the major flaw is that it cannot help but wait when banks start lending freely and unfreeze the credit markets, stimulating business activity. Thus, as far as the effects go, it seems likely that if the banks refrain from lending even at the now cheaper interest rates and merely choose to sit on the cash, it is highly likely that the plan would fail plunging America into a recession. This lack of financial facilitation will also affect the world as the USA is acting as a demand powerhouse for the world.It is likely that the World may move into recession too as export markets in America contract. On the other hand, if the plan was to succeed in unfreezing the credit markets and stimulating business activity, we will see inflation followed by bouts of constrained monetary betterment. This would help the world economy too as exports will be less affected and American consumption will fuel their growth. However, in either case, these 700 billion dollars will ultimately affect the taxpayer in future years, in the form of an increased tax liability.However, the most worrying thought is that the recovery could be a jobless one. The bail out plan may put back business and consumer confidence back on track but the increased money supply might not affect unemployment levels in a major way as US firms continue to move production facilities abroad. Therefore, a coherent strategy aimed at increasing industrial production and reducing unemployment inside the US is augmented. For this reason, other counties, possibly China will have to step up and act as a demand generator. (Shafi 2008)To conclude, if the plan is not able to unfreeze the credit markets, there is little chance that the world might escape a depression. If the plan was to work, two scenarios present themselves. By returning to the old way of consuming more, the US Treasury will allow the legacy of the old system to survive. Instead, if the focus would be towards industrial and export led growth, the system of budget deficits and trade deficits and the large sums of money conjured in maintaining them will die and a new world order built on fiscal facilitation and sound monetary management will evolve.References: Hudson, Michael (2008). The bailout is a giveaway that will cause hyperinflation and dollar collapse. The Real News. Retrieved on 13-12-2008 Lipsey G. , H. & Harbury, C. (1992) First Principles of Economics. London: Oxford University Press. Shafi, A. (2008). A Walk Down Memory Lane: The Sub Prime Mortage Crisis and the Great Depression revisited. The Financial Flicker Retrieved on 13-12-2008 UBS. (2008) There is no alternative. â€Å"Policy measures are anti-deflationary. They are not inflationary. † Retrieved on 13-12-2008

Information And Theory Of Security Management - 1062 Words

HOME SECURITY VULNERABILITIES IN NORTHSIDE Aaron Sneddon DeVry University PRINCIPLES AND THEORY OF SECURITY MANAGEMENT (SEC310) James Leiman March 15, 2015 Introduction In this day and age everyone has to be concerned with security threats that could occur at their home. According to Safeguard, â€Å"2,000,000 home burglaries are reported each year in the United States† (2010). Since there are so many burglaries a year in the United Stated, you need to understand what your current security standings is in your residence and then also understand what you can do to improve it. I have been living in the Northside area in Cincinnati for the past two years. The building that I currently live in has built layers of security by having a fence, doors, lighting and cameras to watch over the place. Security Assessment I currently live in the American Can Lofts that are located in Northside in Cincinnati. The Northside area has a perception of a being an unsafe area as it is near the college campus and the income is lower. According to Areavibes, â€Å"The estimated Northside crime index is 4% higher than the Cincinnati average and the Cincinnati crime index is 110% higher than the Ohio average† (2015). So the crime index is higher for Northside area, but not that much different from Cincinnati. I feel pretty safe walking around the neighborhood as you can see police officers patrolling occasionally. There is also usually a good amount of people walking around. The first layerShow MoreRelatedAn Evaluation of Information Security and Risk Management Theories1903 Words   |  8 PagesAn abundance of information security and risk management theories are prevalent; however, it can be difficult to identify valid and applicable theories. In the reading to follow, several information security and risk management theories are evaluated. 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Themes in Albert Camus quot;The Plague.quot; Essay

Albert Camus was born on the 7th of November 1913 in Mondovi, Algeria to Lucien Camus, whose family had settled in Algeria in 1871, and Catherine Sintes, of Spanish origin. During Camus high school years, he met Jean Grenier, the man who would influence Camus career to the greatest extent by opening his mind to the philosophy of thinkers such as Nietzsche and Bergson. He and Grenier focused much of their writing on the duality of mortality. Still achieving highly at school, Camus received his diploma from the University in philosophy in 1936, examining the legacies and conflicts of thought in his thesis, which would later inhabit his works. The philosophy of moralism he formulated led to his ideas of the absurd, a state which can†¦show more content†¦Individuals were regarded as free to determine themselves through such choices. A pessimist mood characterised the early post-war years reflected in Jean Paul Sartres philosophy of existentialism. This was the backdrop under which Camus wrote. The Plague is classified under the genre of Impressionistic realism. There is no doubt that the book was written as an allegorical experience of the author living in German occupied France during the Second World War. The book is also read as, the occupation of Algeria by France. Another interpretation of the book is that the book is a critique of totalitarian communist ideology, in which the plague symbolises the repression of the people by a ruthless government machinery. My attempt in this paper, though, is to bring out the various themes present in the novel. Through this book, Camus tries to portray mans fight against an all pervading and arbitrary enemy. The entire novel can be viewed as a statement about life and death, i.e. about human existence in general. As with his other novels, The Plague deals with conflicts and struggles, freedom and responsibility, alienation and the difficulty in facing life without belief in God or in absolute moral standards. Other major themes one finds interwoven into this novel are suffering, separation, sickness, rebellion, sympathy, and mechanisation of life. In the novel an epidemic ravages the commercial port town of Oran, in Algeria. The early symptoms likeShow MoreRelatedThe Portrayal of Society in Of Mice and Men and The Outsider Essay1430 Words   |  6 Pages(1902-1968). John Steinbeck writes mainly short stories and novels, he was born in Salinas California, which is the same area where the book of mice and men is set. He is became widely known thanks to his peace: tequila flat. Steinbecks novels have themes of social criticism in them, a lot about the economic problems in rural labor. Good examples of books written by John Steinbeck: dubious battle (1936), of mice and men (1937), the long valley (1938) and east of Eden (1952). The story line is writtenRead MoreExistentialism vs Essentialism23287 Words   |  94 Pages Existentialism can also be difficult to understand because it does not consist of a specific dogma, or a set of metaphysical claims. Existentialism is not a definitive claim about the world or the people in it. It is marked, instead, by a set of themes about the human condition and the struggles and freedoms that humans must endure, or perhaps embrace. Despite the various and often conflicting views held by many existentialist philosophers, there are several main concepts of existentialism that